![]() ![]() ![]() Methods of manufacture are disclosed in Ott et al., 2000 (The Adjuvant MF59: A 10-year Perspective. The present invention relates to processes for the production of oil in water emulsions. The present invention relates to improved processes for the production of oil in water emulsions, in particular, submicron oil in water emulsions comprising squalene. The process of claim 21 further comprising the step of f) subjecting the oil in water emulsion of step e) to high pressure homogenization to form a submicron oil in water emulsion. ![]() The process of claim 12 comprising the step e) mixing the oil and aqueous phases to form an oil in water emulsion.Ģ2. The process according to claim 12 wherein step c) is performed while applying a positive pressure in the oil phase mixing device or step d) is performed while applying positive pressure in the aqueous phase mixing device or steps c) and d) are performed while applying a positive pressure in the oil phase and aqueous phase containing mixing devices.Ģ1. The process of claim 1 further comprising step c) introducing the aqueous phase into a mixing device or step d) introducing an oil phase into a mixing device or both step c) and step d).ġ8. The process of claim 6 wherein the buffer comprises a sodium citrate-citric acid buffer or is a phosphate-buffered saline (PBS) solution.ġ5. The process of claim 1 wherein an aqueous solution comprising a buffer is used in both step a) and step b).ġ2. The process of claim 9 wherein the aqueous solution of step b) comprises a buffer.ġ1. The process of claim 1 wherein water is used in step a).ġ0. The process of claim 7 wherein water is used in step b).ĩ. The process of claim 1 wherein the aqueous solution of step a) comprises a buffer.Ĩ. The process of claim 1 wherein the surfactant is polyoxyethylene sorbitan monooleate.ħ. The process of claim 1 wherein the aqueous phase comprises between about 80% and about 98%, (v/v) of the oil in water emulsion.Ħ. The process of claim 1 wherein the surfactant solution is added to a volume of water or aqueous solution greater than the volume of the surfactant solution using a pump.ĥ. The process of claim 1 wherein the volume of surfactant solution comprises about 0.001% to about 40%, (v/v) of the total volume of the aqueous phase.Ĥ. A process for the production of an oil in water emulsion comprising the steps of: a) dissolving a surfactant in a volume of water or aqueous solution to produce a surfactant solution and b) diluting the surfactant solution in a volume of water or aqueous solution greater than the volume of the surfactant solution to produce an aqueous phase, wherein the volume of oil in water emulsion to be produced is more than about 25 to 550 litres (L) scale.Ģ. Immunotherapeutic Formulations with Interleukin-2-Neutralizing CapacityĬOMPOSITIONS OF ENHANCED VISCOSITY, CLARITY, OR BOTH ENHANCED VISCOSITY AND CLARITYġ. Method for the diagnosis of helicobacter pylori infection and diagnostic kit for performing the method Ophthalmic compositions comprising Aloe Vera Novel Gene Therapy Approach For Treating The Metabolic Disorder ObesityĪgents for Activating the Transcription Factor Nrf2 and Foods Having Such Function PERSONAL CARE COMPOSITIONS WITH GLYCERIN AND HYDROXYPROPYL QUATERNARY AMMONIUM SALTS Mono-and bi-functional antibody conjugates as effective adjuvants of protein vaccination INFLUENZA HEMAGGLUTININ COMPOSITIONS AND USES THEREOFĪMOROLFINE PATCH FOR THE TREATMENT OF ONYCHOMYCOSIS ![]()
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